Clin Endosc.  2016 Sep;49(5):454-456. 10.5946/ce.2016.077.

Endoscopic Mucosal Resection versus Endoscopic Submucosal Dissection for Large Polyps: A Western Colonoscopist's View

Affiliations
  • 1Department of Gastroenterology, Stanford University School of Medicine, Stanford, CA, USA.
  • 2VA Palo Alto Health Care System, Palo Alto, CA, USA. shai_friedland@yahoo.com

Abstract

To discuss the rationale for the widespread application of endoscopic mucosal resection (EMR) rather than endoscopic submucosal dissection (ESD) in Western centers. In Western centers, EMR is the treatment of choice for most non-pedunculated colorectal adenomas >2 cm in size. EMR is sufficiently effective and safe to be performed without post-procedure hospitalization. Advances in EMR have led to reduced recurrence rates, and recent studies have demonstrated excellent outcomes with endoscopic treatment of recurrent adenomas. While studies from Asia have demonstrated lower recurrence rates with ESD, concern about the higher perforation risk and lengthy procedure time of ESD are two of the barriers preventing widespread adoption of ESD in the West. EMR is likely to continue as the dominant method for the treatment of large colorectal adenomas in Western centers until the limitations of ESD are overcome.

Keyword

Colonic polyps; Colonoscopy; Colorectal neoplasms

MeSH Terms

Adenoma
Asia
Colonic Polyps
Colonoscopy
Colorectal Neoplasms
Hospitalization
Methods
Polyps*
Recurrence

Reference

1. Klein A, Bourke MJ. Advanced polypectomy and resection techniques. Gastrointest Endosc Clin N Am. 2015; 25:303–333.
Article
2. Moss A, Bourke MJ, Williams SJ, et al. Endoscopic mucosal resection outcomes and prediction of submucosal cancer from advanced colonic mucosal neoplasia. Gastroenterology. 2011; 140:1909–1918.
Article
3. Saito Y, Uraoka T, Yamaguchi Y, et al. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc. 2010; 72:1217–1225.
Article
4. Moss A, Williams SJ, Hourigan LF, et al. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study. Gut. 2015; 64:57–65.
Article
5. Kim HG, Thosani N, Banerjee S, Chen A, Friedland S. Effect of prior biopsy sampling, tattoo placement, and snare sampling on endoscopic resection of large nonpedunculated colorectal lesions. Gastrointest Endosc. 2015; 81:204–213.
Article
6. Burgess NG, Pellise M, Nanda KS, et al. Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps. Gut. 2016; 65:437–446.
Article
7. Rey JW, Kiesslich R, Hoffman A. New aspects of modern endoscopy. World J Gastrointest Endosc. 2014; 6:334–344.
Article
8. Holmes I, Kim HG, Yang DH, Friedland S. Avulsion is superior to argon plasma coagulation for treatment of visible residual neoplasia during EMR of colorectal polyps (with videos). Gastrointest Endosc. 2016; Apr. 11. [Epub]. http://dx.doi.org/10.1016/j.gie.2016.03.1512.
9. Klein A, Jayasekeran V, Hourigan LF, et al. A multi-center randomized control trial of thermal aablation of the margin of the post endoscopic mucosal resection (EMR) mucosal defect in the prevention of adenoma recurrence following EMR: preliminary results from the “SCAR” study. Gastroenterology. 2016; 150(4 Suppl 1):S1266–S1267.
10. Binmoeller KF, Weilert F, Shah J, Bhat Y, Kane S. “Underwater” EMR without submucosal injection for large sessile colorectal polyps (with video). Gastrointest Endosc. 2012; 75:1086–1091.
Article
11. Kim HG, Thosani N, Banerjee S, Chen A, Friedland S. Underwater endoscopic mucosal resection for recurrences after previous piecemeal resection of colorectal polyps (with video). Gastrointest Endosc. 2014; 80:1094–1102.
Article
12. Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD, Garcia-Kennedy R. Attempted underwater en bloc resection for large (2-4 cm) colorectal laterally spreading tumors (with video). Gastrointest Endosc. 2015; 81:713–718.
Article
13. Oka S, Tanaka S, Saito Y, et al. Local recurrence after endoscopic resection for large colorectal neoplasia: a multicenter prospective study in Japan. Am J Gastroenterol. 2015; 110:697–707.
Article
14. Tomiki Y, Kawai M, Takehara K, et al. Clinical pathway to discharge 3 days after colorectal endoscopic submucosal dissection. Dig Endosc. 2015; 27:679–686.
Article
15. Tanaka S, Kashida H, Saito Y, et al. JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc. 2015; 27:417–434.
Article
Full Text Links
  • CE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr