Korean Circ J.  2016 Nov;46(6):791-797. 10.4070/kcj.2016.46.6.791.

The Relationship between Angiotensin-II Type 1 Receptor Gene Polymorphism and Repolarization Parameters after a First Anterior Acute Myocardial Infarction

• Ozturk O
• Ozturk U
• Nergiz S
• Karahan MZ

• KMID: 2355454
• DOI: http://doi.org/10.4070/kcj.2016.46.6.791

Abstract

BACKGROUND AND OBJECTIVES
Genetic influence on T-wave peak to End (Tpe) time in patients with a first anterior acute myocardial infarction (AMI) is uncertain. A polymorphism in the angiotensin-II type 1 receptor (AT1R) gene was discovered recently. The polymorphism consists of an A or C variant, given three different possible genotypes: AA, AC, CC. The purpose of this study was to determine the effects of polymorphism of the AT1R gene polymorphism on Tpe after a first anterior AMI.
SUBJECTS AND METHODS
The subjects were 142 patients (110 men, 32 women, 58±13 years) with a first anterior AMI; ten patients were excluded from this study. Based on the polymorphism of the AT1R gene, they were classified into two groups: Group 1 (AA genotype) of 91 patients and group 2 (AC and CC genotype) of 41 patients. A 12-lead resting ECG was recorded at admission to the coronary care unit in patients with anterior AMI and were manually measured with a ruler. QTc, QTd, QTcd, Tpe, Tpe/QT parameters were measured.
RESULTS
There was no significant difference in the baseline characteristics of patients (p>0.05). We found significant reduction in QTc, QTd, QTcd, Tpe, Tpe/QT indices Group 1 (AA genotype) (mean 66±28 ms) than group 2 (AC and CC genotype) (mean 95±34 ms) (p<0.05).
CONCLUSION
In patients with a first anterior AMI, AT1R gene polymorphisms may influence on repolarization parameters. Although further studies are required.

Keyword

Genetic; Polymorphism; Myocardial infarction; Electrocardiography

MeSH Terms

Coronary Care Units
Electrocardiography
Female
Genotype
Humans
Male
Myocardial Infarction*

Figure

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  Fig. 1 Gel electrophoresis of the AT1R polymorphism. 0: a DNA size marker (100bp),1: AA, 2: CC, 3: AA, 4: AC, 5: CC, 6: CC, 7: AA, 8: CC, 9: CC, 10: AA, 11: AA, 12: AC, 13: AA, 14: AC, 15: AA, 16: AA, 17: AA.

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