Ann Pediatr Endocrinol Metab.  2015 Dec;20(4):206-212. 10.6065/apem.2015.20.4.206.

Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam

• Lee JH
• Kim YM
• Kwak MJ
• Kim SY
• Kim HJ
• Cheon CK
• Chung WY
• Choi IJ
• Hong SY
• Chueh HW
• Yoo JH

• KMID: 2354697
• DOI: http://doi.org/10.6065/apem.2015.20.4.206

Abstract

PURPOSE
This study investigated the incidence trends and associated factors of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in children and adolescents under 15 years of age in Busan and Gyeongnam, Korea from 2001 to 2010.
METHODS
Medical records of newly diagnosed diabetes patients (n=328; 160 males, 168 females) were collected in questionnaire form from 5 tertiary and 42 general hospitals in Busan and Gyeongnam.
RESULTS
The average crude incidence rate of T1DM and T2DM was 2.01/100,000 (95% confidence interval [CI], 1.76-2.28) and 0.75/100,000 (95% CI, 0.60-0.92), respectively. The incidence rate ratio (IRR) of T1DM was 1.31 (95% CI, 1.01-1.69), and that of T2DM was 1.97 (95% CI, 1.25-3.11) in the latter half-decade (2006 to 2010) compared to the early half-decade (2001 to 2005). There were gradually increasing incidence trends in both T1DM and T2DM over the 10-year period (P for trend: T1DM, 0.0009; T2DM, <0.0001). Age-specific IRR was highest in the 10- to 14-year-old group, regardless of diabetes type. In particular, a rapid increase in incidence of T2DM occurred in the 10- to 14-year-old group. IRR for females was 1.07 (95% CI, 0.83-1.38) for T1DM and 1.56 (95% CI, 1.01-2.41) for T2DM. IRR for Busan (urban) was 1.41 (95% CI, 1.09-1.83) for T1DM and 1.49 (95% CI, 0.96-2.30) for T2DM.
CONCLUSION
T1DM and T2DM incidence both increased over time in youth under age 15 living in Busan and Gyeongnam; in particular, the incidence of T2DM in adolescents increased more rapidly.

Keyword

Diabetes; Korea; Incidence; Child; Adolescent

MeSH Terms

Adolescent*
Busan*
Child*
Cohort Studies*
Diabetes Mellitus*
Diabetes Mellitus, Type 2
Female
Hospitals, General
Humans
Incidence*
Korea
Male
Medical Records
Retrospective Studies*

Figure

• 

  Fig. 1 Procedures: analysis of incidence trends and associated factors of diabetes mellitus in children and adolescents, aged 0-14 years, in Busan and Gyeongnam, Korea (2001-2010).

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  Fig. 2 Incidence of type 1 (A) and type 2 (B) diabetes mellitus in children and adolescents, aged 0-14 years, in Busan and Gyeongnam, Korea (2001-2010). The confidence interval (CI) was calculated using a Poisson distribution. The incidence rate was fitted, and a linear trend test was completed using a Poisson linear regression model.

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  Fig. 3 Diabetes mellitus incidence in children and adolescents, aged 10-14 years, in Busan and Gyeongnam, Korea (2001-2010). T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus. The incidence rate was fitted, and a linear trend test was performed with the Poisson linear regression model.

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