Ann Dermatol.  2015 Jun;27(3):310-314. 10.5021/ad.2015.27.3.310.

Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma

• Jeong DS
• Park DH
• Kim CY

• KMID: 2352503
• DOI: http://doi.org/10.5021/ad.2015.27.3.310

Abstract

Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely metastasizes cutaneously. We report a case of cutaneous metastatic undifferentiated pleomorphic sarcoma of the buttocks occurring in a 73-year-old man diagnosed with mediastinal sarcoma 4 years previously. He first noticed the mass approximately 2 months previously. Histological findings with immunomarkers led to a final diagnosis of cutaneous metastatic sarcoma from mediastinal undifferentiated pleomorphic sarcoma.

Keyword

Malignant fibrous histiocytoma; Undifferentiated pleomorphic sarcoma

MeSH Terms

Aged
Buttocks
Diagnosis
Histiocytoma, Malignant Fibrous
Humans
Lower Extremity
Sarcoma*
World Health Organization

Figure

• 

  Fig. 1 (A) A solitary hard deep seated nodule in the right buttock. (B) Close-up of the nodule in (A). Axial (C) and sagittal (D) computed tomography images showing a 3×4 cm irregularly shaped metastatic soft tissue mass in the subcutaneous layer of the right buttock.

• 

  Fig. 2 The mediastinal tumor 4 years previously (H&E; A: ×12.5, B: ×200). The tumor was composed of spindle-shaped cells arranged in a storiform pattern with atypical mitoses the same findings were observed in the mediastinal tumor upon recurrence (H&E; C: ×12.5, D: ×400) and metastatic tumor in the buttock (H&E; E: ×12.5, F: ×400).

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