Yeungnam Univ J Med.  1994 Jun;11(1):167-180. 10.12701/yujm.1994.11.1.167.

Effects of the Selective Management for Increased Intracranial Pressure with Obstruction of Internal Carotid Artery in Rabbits

• Kim BD
• Lee KY
• Kim SH
• Han DR
• Bae JH
• Kim OL
• Choi BY
• Cho SH
• Shin HJ

• KMID: 2352277
• DOI: http://doi.org/10.12701/yujm.1994.11.1.167

Abstract

In order to inquire the most-effective management of increased intracranial pressure(ICP), mannitol, steroid and hyperventilation were used in rabbits after ligation or non-ligation of the carotid artery. Mannitol was more effective than steroid and hyperventilation in the degree of the reduction of ICP. The intracranial pressure was decreased 43~45% for 25~30 minutes after injection of mannitol. Steroid was less effective than mannitol in the degree of the reduction of ICP. But the time of reduction of ICP was longer, that is, the degree of reduction was 24~60 minutes after injection of steroid. Hyperventilation is effective in the initial time only, for 10 minutes after hyperventilation. The degree of ICP reduction was 13.5~16.7 % for 10 minutes after hyperventilation. The combined group, that is three kinds of mangenent were used, is the most effective treatment to reduce ICP of ICP. The degree of the reduction of ICP was 42.1~49.3% for 20 minutes, 47.7~52.5% for 30minnutes. There was no significant difference between and non-ligation group.

MeSH Terms

Carotid Arteries
Carotid Artery, Internal*
Hyperventilation
Intracranial Pressure*
Ligation
Mannitol
Rabbits*
Mannitol