J Korean Orthop Assoc.  2016 Aug;51(4):345-349. 10.4055/jkoa.2016.51.4.345.

Neurolymphomatosis Involving Antebrachial Cutaneous Nerve

• Jung YH
• Song WS
• Park SR
• Paik SY

• KMID: 2348642
• DOI: http://doi.org/10.4055/jkoa.2016.51.4.345

Abstract

The term neurolymphomatosis has included infiltration of the peripheral nervous system by lymphoma. In generally, direct invasion of the peripheral nervous system is rare. The difficulty in treatment of neurolymphomatosis is due to unclassified characteristic symptoms and diagnosis. We performed excision of mass on the antebrachial cutaneous nerve with no specific symptoms. After diagnosis of diffuse large B cell lymphoma, further treatment and observation were followed. However, recurrence of the lymphoma was found in the ipsilateral forearm ulnar nerve, therefore we described a case of neurolymphomatosis with a brief review of the literature.

Keyword

neurolymphomatosis; diffuse large B cell lymphoma; antebrachial cutaneous nerve; ulnar nerve

MeSH Terms

Animals
Diagnosis
Forearm
Lymphoma
Lymphoma, B-Cell
Marek Disease*
Peripheral Nervous System
Recurrence
Ulnar Nerve

Figure

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  Figure 1 Intermediate/heterogeneous high signal in T2 weighted (A), contrast enhanced (B), T1 weighted (C) magnetic resonance imaging of the right foream volar side shows that a well marginated ovoid mass passes through the anterior or lateral antebracial cutaneous nerve.

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  Figure 2 Diffuse infiltration of large to medium sized neoplastic lymphoid cells. Note lymphoma cells invading a large nerve bundle (H&E, ×200).

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  Figure 3 Immunohistochemical stains showed the tumor cells to be diffusely positive to CD20 (A) and Bcl-2 (B) (A, B: ×200).

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  Figure 4 T2 weighted (A) and contrast enhanced (B) magnetic resonance imaging of the right medial elbow side shows that the lobulated enhancing mass passes through the ulnar nerve course.

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