J Korean Radiol Soc.  1992 Dec;28(6):977-984.

Arterial thrombotic occlusions following percutaneous catheterization in infants and children: local thrombolytic therapy with urokinase

• Kim YJ

Abstract

Six cases of right external iliac and common femoral arterial thrombotic occlusions following transfemoral cardiac catheterization were found among the 117 infants and children with congenital heart disease. Physical findings of arterial thrombosis were lower extremity coldness and absence of femoral pulse, which appeared just after cardiac catheterization. Transcatheter local intrathrombotic infusion of Urokinase were done with 50000 IU bolus doses and 40000-50000 IU/h running doses. All 6 cases showed complete thrombolysis and re-establishment of femoral circulation. Three cases developed bleeding from arterial puncture sites, and were subsequently controlled properly by compression. No other complication was found. Our results suggest that local thrombolytic therapy with Urokinase is effective treatment method without significant complication for the infants and children with fresh thrombotic occlusions following cardiac catheterization and angiography.

MeSH Terms

Angiography
Cardiac Catheterization
Cardiac Catheters
Catheterization*
Catheters*
Child*
Heart Defects, Congenital
Hemorrhage
Humans
Infant*
Lower Extremity
Methods
Punctures
Running
Thrombolytic Therapy*
Thrombosis
Urokinase-Type Plasminogen Activator*
Urokinase-Type Plasminogen Activator