J Gynecol Oncol.  2015 Oct;26(4):252-254. 10.3802/jgo.2015.26.4.252.

A critical assessment on the role of sentinel node mapping in endometrial cancer

• Bogani G
• Ditto A
• Martinelli F
• Signorelli M
• Perotto S
• Lorusso D
• Raspagliesi F

• KMID: 2345914
• DOI: http://doi.org/10.3802/jgo.2015.26.4.252

Abstract

Endometrial cancer is the most common gynecologic malignancy in the developed countries. Although the high incidence of this occurrence no consensus, about the role of retroperitoneal staging, still exists. Growing evidence support the safety and efficacy of sentinel lymph node mapping. This technique is emerging as a new standard for endometrial cancer staging procedures. In the present paper, we discuss the role of sentinel lymph node mapping in endometrial cancer, highlighting the most controversies features.

Keyword

Endometrial Neoplasms; Hysteroscopic Injection; Lymph Node Excision; Sentinel Node

MeSH Terms

Endometrial Neoplasms/*pathology/surgery
Female
Humans
Hysteroscopy/methods
Injections, Intralesional
Lymph Node Excision/*methods
Lymphatic Metastasis
*Sentinel Lymph Node Biopsy/methods

Reference

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015; 65:5–29.

2. American College of Obstetricians and Gynecologists. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol. 2005; 106:413–425.

3. Kumar S, Podratz KC, Bakkum-Gamez JN, Dowdy SC, Weaver AL, McGree ME, et al. Prospective assessment of the prevalence of pelvic, paraaortic and high paraaortic lymph node metastasis in endometrial cancer. Gynecol Oncol. 2014; 132:38–43.

4. May K, Bryant A, Dickinson HO, Kehoe S, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev. 2010; (1):CD007585.

5. Cormier B, Rozenholc AT, Gotlieb W, Plante M, Giede C. Communities of Practice (CoP) Group of the Society of Gynecologic Oncology of Canada (GOC). Sentinel lymph node procedure in endometrial cancer: a systematic review and proposal for standardization of future research. Gynecol Oncol. 2015; 138:478–485.

6. Naoura I, Canlorbe G, Bendifallah S, Ballester M, Darai E. Relevance of sentinel lymph node procedure for patients with high-risk endometrial cancer. Gynecol Oncol. 2015; 136:60–64.

7. Benedetti Panici P, Basile S, Salerno MG, Di Donato V, Marchetti C, Perniola G, et al. Secondary analyses from a randomized clinical trial: age as the key prognostic factor in endometrial carcinoma. Am J Obstet Gynecol. 2014; 210:363.e1–363.e10.

8. Eriksson AG, Ducie JA, Ali N, McGree M, Weaver AL, Bogani G, et al. Multicenter study comparing two approaches to nodal assessment in patients with low-risk endometrial carcinoma: contemporary sentinel lymph node mapping versus historical selective systematic surgical staging. Gynecol Oncol. 2015; 137:Suppl 1. 6–7.

9. Ducie JA, Eriksson AG, Ali N, McGree M, Weaver AL, Bogani G, et al. Multicenter study assessing the detection of stage IIIC endometrial cancer in intermediate- and high-risk tumors between a contemporary sentinel node mapping versus historical comprehensive lymphadenectomy approach. Gynecol Oncol. 2015; 137:Suppl 1. 7.

10. Raspagliesi F, Ditto A, Kusamura S, Fontanelli R, Vecchione F, Maccauro M, et al. Hysteroscopic injection of tracers in sentinel node detection of endometrial cancer: a feasibility study. Am J Obstet Gynecol. 2004; 191:435–439.

11. Niikura H, Kaiho-Sakuma M, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, et al. Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2013; 131:299–303.

12. Kato K, Tate S, Nishikimi K, Shozu M. Surgical anatomy of the common iliac veins during para-aortic and pelvic lymphadenectomy for gynecologic cancer. J Gynecol Oncol. 2014; 25:64–69.

13. AlHilli MM, Mariani A. Preoperative selection of endometrial cancer patients at low risk for lymph node metastases: useful criteria for enrollment in clinical trials. J Gynecol Oncol. 2014; 25:267–269.

14. Mitamura T, Watari H, Todo Y, Kato T, Konno Y, Hosaka M, et al. Lymphadenectomy can be omitted for low-risk endometrial cancer based on preoperative assessments. J Gynecol Oncol. 2014; 25:301–305.

15. Bogani G, Chiappa V, Lorusso D, Raspagliesi F. Treatment of recurrent endometrial carcinoma: progress toward a more personalized approach. J Clin Oncol. 2015; 08. 03. [Epub]. DOI: 10.1200/JCO.2015.61.4636.