Ann Dermatol.  2016 Aug;28(4):497-498. 10.5021/ad.2016.28.4.497.

Extramammary Paget's Disease Combined with Squamous Cell Carcinoma In Situ of the Vulva: A Case Report and Differential Diagnosis

• Jang EJ
• Bae YK
• Shin DH
• Lee DJ

• KMID: 2344823
• DOI: http://doi.org/10.5021/ad.2016.28.4.497

Abstract

No abstract available.

MeSH Terms

Carcinoma, Squamous Cell*
Diagnosis, Differential*
Epithelial Cells*
Paget Disease, Extramammary*
Vulva*

Figure

• 

  Fig. 1 (A) Scanning view of partial vulvectomy specimen (H&E, ×8). Surface erosion is noted in the right upper portion of the figure. (B) The right side of Fig. 1A (★) represented extramammary Paget's disease (H&E, ×200) and (C) the left side of Fig. 1A (▼) showed squamous intraepithelial lesion including carcinoma in situ of the vulva (H&E, ×200).

• 

  Fig. 2 Immunohistochemical results showed distinct patterns in extramammary Paget's disease (A~D) and squamous carcinoma in situ (E~H). Paget's cells were strongly positive for CK7 (A) and focally positive for carcinoembryonic antigen (CEA) (B), but negative for CK5/6 (C) and p63 (D). Non-neoplastic keratinocytes are positive for CK5/6 and p63. The tumor cells of squamous carcinoma in situ were totally negative for CK7 (E) and CEA (F), but positive for CK5/6 (G) and p63 (H) (A~H, ×200).

Reference

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