J Korean Neurol Assoc.  2008 Nov;26(4):323-332.

Is Obstructive Sleep Apnea a Risk Factor of Subclinical White Matter Damages?

Affiliations
  • 1Department of Neurology, School of Medicine, Ewha Womans University and Ewha Medical Research institute, Seoul, Korea. leeh@ewha.ac.kr
  • 2Department of Neurology, Dankook University College of Medicine, Cheonan, Korea.

Abstract

BACKGROUND
Obstructive sleep apnea (OSA) has been reported to increase risk of ischemic stroke. This study was performed to investigate the prevalence and relationship of subclinical white matter damages (SD) in patients with OSA.
METHODS
All subjects (n = 54) had brain MRI and nocturnal polysomnogram (PSG). SD are defined by nonsymptomatic lacunar infarcts > 3 mm or periventricular white matter changes (PVWC). We analyzed the difference between OSA patients with and without SD (SD and non-SD groups), and also with and without PVWC. Using apnea-hypopnea index (AHI), we classified OSA into mild (5< or =AHI< or =15) and moderate to severe (AHI>15).
RESULTS
SD group (n = 31) showed significantly increased apnea-hypopnea index (AHI), apnea index (AI) and oxygen desaturation index (ODI) compared to non-SD (n = 23). Among the 37 patients without lacunar infarctions, 14 showed PVWC while the other 23 did not have any lesions. Compared to non-SD group, SD group showed increased AHI and ODI, and decreased lowest SaO2 (p < 0.05). Similarly, AHI and ODI were higher and the lowest SaO2 was lower in patients with PVWC than without PVWC (p < 0.05). Moderate to severe OSA group showed more frequent subclinical or periventricular white matter changes than mild group (p < 0.05).
CONCLUSIONS
Severity of OSA showed a positive correlation with the occurrence of subclinical white matter damages. OSA may cause subclinical white matter damages.

Keyword

Obstructive sleep apnea; Subclinical white matter damage; Oxygen desaturation

MeSH Terms

Apnea
Brain
Humans
Oxygen
Prevalence
Risk Factors
Sleep Apnea, Obstructive
Stroke
Stroke, Lacunar
Oxygen
Full Text Links
  • JKNA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr