J Korean Neurol Assoc.
2000 Jul;18(4):483-485.
Lennox-Gastaut Syndrome Associated with Gangliocytoma: A Case of Surgical Treatment
- Affiliations
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- 1Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan.
- 2Department of Neurosurgery, Asan Medical Center, College of Medicine, University of Ulsan.
Abstract
- We report a case of Lennox-Gastaut syndrome successfully treated by the removal of hippocampal gangliocytoma. A17-year-old girl was admitted due to intractable tonic seizure, generalized tonic clonic seizure, and frequent fallingdespite the administration of polypharmacotherapy. She was mentally retarded and had developmental delays. She had the first seizure at the age of 12 months and the pattern of seizures seemed to be drop attacks. Electroencephalogram (EEG) showed background slowing of about 7 Hz, multifocal spike and wave, and generalized spike and wave complex-es (1.5~3.5 Hz). Magnetic resonance image (MRI) revealed a small polycystic mass in the left parahippocampal gyrus and hippocampal atrophy. A left hippocampectomy and total resection of the tumor was performed. Histopathologically, the cysts were identical to gangliocytoma. Sixth months later, the frequency of seizures decreased to once a month No seizures have been reported since August 1998.
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