J Korean Neurol Assoc.  1995 Jun;13(2):224-232.

The Effect of Carbamazepine-Controlled Release on the Congnitive Function

• Kim KJ
• Kim JW
• Kim SH
• Ha KM
• Lee SK

Abstract

We evaluated the effect of carbamazepine-controlled release (CR) on the cognitive function. By using monotherapy study, we investigated the effects of carbamazepine on cognitive function in 10 epileptic patients and 17 normal controls. The evaluations were conducted before and one and six months after therapy using neuropsychological batteries(BUSCHKE SELECTIVE REMINDING TEST BSRT, REY OSTERRIETH COMPLEX FIGURE TEST ROCFT, CONCENTRATION ENDURANCE TEST d2 test, REY VISUAL DESIGN LEARNING TEST RVDLT, FINGER TAPPING TEST). In the patients treated with carbamazepine-CR monotherapy, follow up studies were made in one and six months later, respectively. It was found that the cognitive function determined in the three tests(consistent long-term retrieval : one item of BSRT, d2 test, and ROCFT : P 0.05). The mean anticonvulsant blood levels on the day of cognitive function tests were 6.48mg/ml (SD=l. 87) and 6.53mg /ml (SD=l.97) in one and six months respectively. This study showed carbamazepine-CR monotherapy had an adverse effect on the cognitive function.

Keyword

Carbamazepine-controlled release; Neuropsychological batteries; Cognitive fiunction impairment

MeSH Terms

Carbamazepine
Fingers
Follow-Up Studies
Humans
Learning
Carbamazepine