J Korean Neuropsychiatr Assoc.
2003 Sep;42(5):565-572.
Association of Functional microOpioid Receptor Genotypes with Alcohol Dependence in Koreans
- Affiliations
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- 1Department of Psychiatry, Pusan National University, Busan, Korea. sungkim@pusan.ac.kr
- 2Department of Biochemistry, Pusan National University, Busan, Korea.
- 3Haeundae Ja Myung Hospital, Busan, Korea.
- 4Department of Family Medicine, Pusan National University, Busan, Korea.
- 5Yang San Hospital, Yang San, Korea.
- 6Division of Management Information Science, Dong-A University, Busan, Korea.
Abstract
OBJECTIVES
Previous studies have shown that the endogenous opioid system, which plays an important role in drinking behavior, might be related to the genetic etiology of alcohol dependence. And a recent study reported that the affinity of micro opioid receptor, which is closely related to the endogenous opioid system activity, is affected by the genotype of micro opioid receptor gene (OPRM1) A118G. The present study examined the association of the genotype of OPRM1 A118G with alcohol dependence in Koreans.
METHODS
The author studied the genotype of OPRM1 A118G in 112 Korean patients with alcohol dependence and 140 healthy Korean control subjects.
RESULTS
1) A statistically significant increase in A/G or G/G genotype of OPRM1 A118G was observed in patients with alcohol dependence (67.0%) compared to the controls (51.4%). 2) Among patients with alcohol dependence, no significant difference in OPRM1 A118G polymorphism was observed relative to the age at which drinking started, the age of onset of alcohol-related problems, the age of first admission to psychiatric hospital for alcohol-related problems, the family history of alcohol dependence in the first-degree relatives or of severe alcohol withdrawal symptoms. But the frequency of A/G or G/G genotypes of OPRM1 A118G was significantly higher in those who drank 17 days or more per month in the previous year (80.8%) than in those with fewer days of drinking (56.5%).
CONCLUSION
These results suggest that A/G or G/G genotypes of micro opioid receptor gene A118G are important genetic factors in the etiology of alcohol dependence.
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