J Korean Neuropsychiatr Assoc.  2002 May;41(3):563-570.

A Case of Leopard Syndrome with Atypical Psychosis

Affiliations
  • 1Department of Neuropsychiatry, Maryknoll Hospital, Busan, Korea.

Abstract

Leopard syndrome is a neurocutaneous syndrome which may affect a variety of organ systems in the embryological aspects. It presents lentigines, EKG abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, and deafness as major teatures.We report a case of Leopard Syndrome with atypical psychotic features. The patient had many lentigenies on the face, cafe au lait spots on the part of the waist and the buttocks, mild atrial regugitation, clinodactyly, hyperextensibility of distal interphalangeal joint, flat foots, subclinical hypothyrodism, sensorineural deafness, and mild mental retardation. He also had autistic disorder, compulsion, pathologic collection, and violent behaviors as psychiatric problems. This raises a possibility that psychiatric diseases may be related to the variation of neuroectoderm. In clinical practice, when psychopathic patients with specific skin lesions are seen for consultation, the consideration of embryologically common aspects of both disease groups can be helpful to the discovery of abnormalities in other organs and to its treatment.

Keyword

Leopard Syndrome; lentigine; Autism

MeSH Terms

Autistic Disorder
Buttocks
Cafe-au-Lait Spots
Deafness
Electrocardiography
Flatfoot
Genitalia
Humans
Hypertelorism
Intellectual Disability
Joints
Lentigo
LEOPARD Syndrome*
Neural Plate
Neurocutaneous Syndromes
Panthera*
Psychotic Disorders*
Pulmonary Valve Stenosis
Skin
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