J Korean Neuropsychiatr Assoc.  2001 Jan;40(1):127-134.

Clinical Availability of Topographic Auditory Event Related Potentials in Children with Attention Deficit Hyperactivity Disorder

• Lim TS
• Han SI
• Jeon YW
• Bang SK

Abstract

OBJECTIVES
This study was carried out to investigate the clinical availability of topographic auditory event related potential P300 as a biological marker in children with attention deficit hyperactivity disorder(ADHD).
METHODS
The subjects were composed of children with ADHD(n=22:16 boys, 6 girl s:mean age=89.8+/-17.1months) and normal controls(n=20:12 boys, 8 girls:mean age=90.6+/-16.8months). Topographic auditory event related potential was measured by "oddball paradigm", and the latencies and amplitudes of P300 of both groups were determined by Global Field Power Measurement. After 8 weeks treatment with methylphenidate, P300 of ADHD children were also measured.
RESULTS
Both P300 latency and amplitude were not different between ADHD children after treatment and normal controls, but significantly different between ADHD children before treatment and normal controls, and between before and after treatment of ADHD children.
CONCLUSIONS
The results implicate that the latency and amplitude of P300 may be considered as state markers of ADHD.

Keyword

Attention deficit hyperactivity disorder(ADHD); Topographic auditory event related potential; P300

MeSH Terms

Attention Deficit Disorder with Hyperactivity*
Biomarkers
Child*
Evoked Potentials*
Female
Humans
Methylphenidate
Methylphenidate