J Korean Neurosurg Soc.  2012 Sep;52(3):246-249.

Intracranial Extraskeletal Myxoid Chondrosarcoma : Case Report and Literature Review

• Park JH
• Kim MJ
• Kim CJ
• Kim JH

Abstract

Intracranial extraskeletal myxoid chondrosarcoma is extremely rare, with only seven patients previously reported. We present a case report of a 21-year-old woman admitted for weakness in her right extremities and symptoms of increased intracranial pressure. Magnetic resonance imaging (MRI) revealed hydrocephalus and a well-enhanced large mass around her left thalamus. A left parietal craniotomy and a cortisectomy at the superior parietal lobule were performed. Total surgical resection was also performed, and pathology results confirmed an extraskeletal myxoid chondrosarcoma. Postoperative MRI showed no residual tumor, and the patient underwent radiotherapy. After six months of radiotherapy, the patient's headache and weakness had improved to grade IV. This malignant tumor showed high rates of recurrence in previous reports. We here report another occurrence of this highly malignant and rare tumor in a patient treated using total surgical excision and adjuvant radiotherapy.

Keyword

Brain neoplasms; Chondrosarcoma; Choroid plexus

MeSH Terms

Brain Neoplasms
Chondrosarcoma
Choroid Plexus
Craniotomy
Extremities
Female
Headache
Humans
Hydrocephalus
Intracranial Pressure
Magnetic Resonance Imaging
Neoplasm, Residual
Radiotherapy, Adjuvant
Recurrence
Thalamus
Young Adult

Figure

• 

  Fig. 1 Imaging findings for the current patient. A : T1-weighted magnetic resonance imaging (MRI) showing homogeneous iso-signal intensity of a 63-mm tumor in the left lateral ventricle along with ventricular dilatation. B : T2-weighted MRI showing a heterogeneous high signal intensity tumor and peritumoral edema. C : T1-weighted enhanced MRI showing strong enhancement of the tumor.

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  Fig. 2 Histologic features of the tumor in the current patient. A : The tumor consists of strands or cords of oval cells and abundant myxoid stroma (H&E, ×100). B : The tumor cells interconnected to form cords and had relatively uniform oval nuclei and a moderate amount of eosinophilic cytoplasm (H&E, ×400). C, D and E : These tumor cells are positive for epithelial membrane antigen (original magnification ×400) (C), microtubule-associated protein 2 (original magnification ×400) (D), and vimentin (original magnification ×100) (E) by immunohistochemical staining.

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