J Korean Ophthalmol Soc.  2014 Jul;55(7):1017-1023.

Peripheral Vascular Leakage Findings of Asymptomatic Eyes Based on Fluorescein Angiography

• Lee SH
• Shin YU
• Lee BR
• Ko MK

Abstract

PURPOSE
To report peripheral vascular retinal leakage findings of asymptomatic eyes based on fluorescein angiography, and investigate the associated factors.
METHODS
Data were collected retrospectively from 47 subjects (94 eyes) and the peripheral leakage results based on fluorescein angiography were analyzed. The relationship between peripheral leakage findings and other factors including-arm-retinal circulation time (ARCT) and venous filling time (VFT), refractive error, age, hypertension, and diabetes- was evaluated.
RESULTS
Ten eyes had peripheral leakage (21.3%). The mean age was 34.7 +/- 7.86 years in the non-leakage group and 44.3 +/- 9.63 years in the leakage group; the difference between the groups was statistically significant (p = 0.001). The mean spherical equivalent was -2.85 +/- 2.71 diopter in the non-leakage group and -3.46 +/- 3.62 diopter in the leakage group; the difference between the groups were not significant (p = 0.471). The mean ARCT was 10.50 +/- 2.06 seconds in the non-leakage group and 11.76 +/- 2.47 seconds in the leakage group; the difference between the groups was statistically significant (p = 0.041). The mean VFT was 9.70 +/- 1.91 seconds in the non-leakage group and 10.75 +/- 1.40 seconds in the leakage group; the difference between the groups was statistically significant (p = 0.048).
CONCLUSIONS
Peripheral leakage can be found in asymptomatic eyes. Age, VFT, and ARCT were correlated to peripheral leakage findings based on angiography. These leakage findings were thought to be related with histological properties and physiological changes in peripheral retina.

Keyword

Arm-retinal circulation time; Fluorescein angiography; Peripheral leakage; Venous filling time

MeSH Terms

Angiography
Fluorescein Angiography*
Hypertension
Refractive Errors
Retina
Retinaldehyde
Retrospective Studies
Retinaldehyde

Figure

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  Figure 1. Peripheral leakage patterns in fluorescein angiography. (A) Temporal localized leakage. (B) Leakage in multiple directions (3 quadrants). (C) Leakage in two directions (temporal, inferonasal).

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  Figure 2. Distribution of associative factors classified according to leakage. (A) Distribution of age, (B) distribution of arm-retinal circulation time (ARCT), (C) distribution of venous filling time (VFT).

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  Figure 3. Graph of Spearman correlation analysis. (A) Age versus venous filling time (VFT), (B) age versus arm-retinal circulation time (ARCT), (C) arm-retinal circulation time (ARCT) versus venous filling time (VFT).

Reference

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