J Korean Ophthalmol Soc.  2011 Sep;52(9):1119-1122.

Reactivation of Herpetic Keratitis in a Patient after Using Two Different Prostaglandin Analogues

• Yang HS
• Park HG
• Choi S

Abstract

PURPOSE
To report a case of herpetic keratitis after administration of two different prostaglandin analogues.
CASE SUMMARY
A 68-year-old female with a history of herpetic keratitis in her right eye after using latanoprost seven years previous presented with redness, mild ocular pain and tearing in the same eye. She had also been prescribed travoprost eye drops for both eyes for uncontrolled glaucoma one month earlier. The cornea in her right eye showed a dendritic epithelial defect with focal epithelial erosions. Travoprost treatment was discontinued, and the herpetic keratitis recovered completely in ten days with acyclovir ointment and oral agent. No further recurrence was observed in the following six months.

Keyword

Herpetic keratitis; Latanoprost; Prostaglandin analogue; Travoprost

MeSH Terms

Acyclovir
Aged
Cloprostenol
Cornea
Eye
Female
Glaucoma
Humans
Keratitis, Herpetic
Ophthalmic Solutions
Prostaglandins F, Synthetic
Prostaglandins, Synthetic
Recurrence
Tears
Travoprost
Acyclovir
Cloprostenol
Ophthalmic Solutions
Prostaglandins F, Synthetic
Prostaglandins, Synthetic

Figure

• 

  Figure 1. A 68-year-old female with focal epitheliopathy after using travoprost for 4 weeks (first visit).

• 

  Figure 2. Dendritic keratitis in the same patient after using travoprost for 1 month (sencond visit).

Reference

References

1. Hong WS, Rhee SW. Clinical observations of herpes keratitis. J Korean Ophthalmol Soc. 1977; 18:129–33.

2. Wand M, Gilbert CM, Liesegang TJ. Latanoprost and herpes simplex keratitis. Am J Ophthalmol. 1999; 127:602–4.

3. Ekatomatis P. Herpes simplex dendritic keratitis after treatment with latanoprost for primary open angle glaucoma. Br J Ophthalmol. 2001; 85:1008–9.

4. Kaufman HE, Varnell ED, Toshida H, et al. Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit. Am J Ophthalmol. 2001; 131:643–6.

5. Camras CB. Latanoprost increases the severity and recurrence of herpetic keratitis in the rabbit; latanoprost and herpes simplex keratitis. Am J Ophthalmol. 2000; 129:271–2.

6. Kaufman HE, Varnell ED, Thompson HW. Latanoprost increases the severity and recurrence of herpetic keratitis in the rabbit. Am J Ophthalmol. 1999; 127:531–6.

7. Kim KE, Moon JI, Chung SK, Baek NH. 3 cases of latanoprost associated herpes simplex keratitis. J Korean Ophthalmol Soc. 2002; 43:1081–5.

8. Kothari MT, Mehta BK, Asher NS, Kothari KJ. Recurrence of bilateral herpes simplex virus keratitis following bimatoprost use. Indian J Ophthalmol. 2006; 54:47–8.

9. Kroll DM, Schuman JS. Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. Am J Ophthalmol. 2002; 133:401–3.

10. Villegas VM, Diaz L, Izquierdo NJ. Herpetic keratitis in a patient who used two different prostaglandin analogue ophthalmic solutions: a case report. P R Health Sci J. 2008; 27:348–9.

11. Kaufman HE, Varnell ED, Centifanto YM, Kissling GE. Effect of the herpes simplex virus genome on the response of infection to corticosteroids. Am J Ophthalmol. 1985; 100:114–8.

12. Gordon YJ, Yates KA, Mah FS, Romanowski EG. The effects of Xalatan on the recovery of ocular herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models. J Ocul pharmacol Ther. 2003; 19:233–45.