J Korean Ophthalmol Soc.  2010 Oct;51(10):1345-1353.

Spectral Domain OCT Findings of Asymptomatic Fellow Eyes in Central Serous Chorioretinopathy

• Cho WB
• Chung H
• Kim HC

Abstract

PURPOSE
To investigate morphologic changes in the asymptomatic fellow eye of central serous chorioretinopathy (CSC) using spectral domain optical coherence tomography (SD OCT).
METHODS
The present retrospective study included 55 asymptomatic fellow eyes of 55 patients with acute CSC. All patients underwent SD OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the results were analyzed.
RESULTS
Sixteen eyes (29.1 %) with normal FA also showed normal SD OCT; however, 70% of the eyes showed choroidal hyperpermeability or punctate hyperfluorescent spots on ICGA. Window defects on FA were observed in 25 eyes (45.5%), and they were represented as a corrugation or bump in the retinal pigment epithelium (RPE) on SD OCT. Retinal pigment epithelial detachments (PEDs) were observed in six eyes (10.9 %) on FA and were represented as PEDs on SD OCT. Leakages on FA were observed in ten eyes (18.2%) and were represented as normal, serous retinal detachment, and a corrugation or bump of RPE on SD OCT.
CONCLUSIONS
Greater information regarding morphologic changes and pathophysiology of CSC can be obtained by investigating SD OCT findings in the asymptomatic fellow eyes of acute CSC.

Keyword

Central serous chorioretinopathy; Spectral domain optical coherence tomography

MeSH Terms

Angiography
Central Serous Chorioretinopathy
Choroid
Eye
Fluorescein Angiography
Humans
Indocyanine Green
Retinal Detachment
Retinal Pigment Epithelium
Retinaldehyde
Retrospective Studies
Tomography, Optical Coherence
Indocyanine Green
Retinaldehyde

Figure

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  Figure 1. Indocyanine green angiography (ICGA) in the asymptomatic fellow eye of a 48-year-old woman with central serous chorioretionpathy. (A) ICGA image from Spectralis HRA shows punctate hyperfluorescent spots in the foveal and peripapillary region at the early phase. (B) ICGA image from TOPCON IMAGEnet shows choroidal hyperpermeability in the foveal and peripapillary region at the mid-phase. Abnormal findings from two different equipments can be seen in the same region.

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  Figure 2. Fellow eyes of the 37-year-old man and the 40-year-old woman with central serous chorioretinopathy. (A-D), There are no abnormal findings on fluorescein angiography and optical coherence tomography. (E,H), Images from indocyanine green angiography of the 37-year-old man are normal. However, images of the 40-year-old woman reveal choroidal hyperpermeability (F) and punctate hyperfluorescent spots (H).

• 

  Figure 3. An asymptomatic fellow eye of the 59-year-old woman with central serous chorioretinopathy. (A) Fluorescein angiography shows multiple window defects. (B,C) Optical coherence tomographic images at the defects of FA. The retinal pigment epithelium layer shows corrugation (B) or hump (C) at the exact same region with a window defect. (D) Indocyanine green angiography (ICGA) using TOPCON IMAGEnet shows choroidal hyperpermeability. (E) ICGA using Spectralis HRA shows punctate hyperfluorescent dots.

• 

  Figure 4. An asymptomatic fellow eye of the 47-year-old woman with central serous chorioretinopathy. There are multiple retinal pigment epithelial detachment (PED) on fluorescein angiography (A). Idnocyanine green angiography shows choroidal hyperpermeability around the PEDs (B). Optical coherence tomography also shows PEDs (C,D,E).

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  Figure 5. Asymptomatic fellow eyes of the 38-year-old woman (A, B, C), 38-year-old man (D, E, F) and 45-year-old woman (G, H, I, J) with central serous chorioretinopathy. Fluorescein angiography (FA) shows leakages at the various regions (A, D, G). Optical coherence tomography (OCT) shows serous neurosensory detachment (B), no structural change (E), bump or corrugation of the retinal pigment epithelium (B, E, H, I). Indocyanine angiography shows punctuate hyperfluorescent spots or choroidal hyperpermeability at the region of leakage (C, F, J).

Reference

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