J Korean Ophthalmol Soc.  2008 Oct;49(10):1634-1640.

Changes in RNFL Thickness According to the Myopia in Patients with Glaucoma and Ocular Hypertension

• Kim JW
• Kim YY

Abstract

PURPOSE
To evaluate the changes in retinal nerve fiber layer (RNFL) thickness according to the degree of myopia in patients with glaucoma and ocular hypertension.
METHODS
Ninety-eight patients (165 eyes) diagnosed with glaucoma or ocular hypertension underwent optical coherence tomography (OCT) and scanning laser polarimetry using variable corneal compensation (GDx-VCC) to analyze the correlation between the degree of myopia and the thickness of the RNFL. A partial correlation coefficient analysis was performed to adjust for various factors such as age, laterality, intraocular pressure, and the mean deviation from visual field test, which can influence the RNFL thickness.
RESULTS
The average, nasal, superior, and inferior sectorial RNFL thicknesses measured by OCT significantly decreased with increasing myopia (p<0.05). However, RNFL thickness measured by GDx-VCC was not significantly correlated with the degree of myopia.
CONCLUSIONS
The RNFL thickness measured by OCT decreased with increasing myopia in eyes with glaucoma and ocular hypertension.

Keyword

GDx-VCC; Myopia; OCT; RNFL thickness

MeSH Terms

Compensation and Redress
Eye
Glaucoma
Humans
Intraocular Pressure
Myopia
Nerve Fibers
Ocular Hypertension
Retinaldehyde
Scanning Laser Polarimetry
Tomography, Optical Coherence
Visual Field Tests
Retinaldehyde

Figure

• 

  Figure 1. Scattergram of the average retinal nerve fiber layer (RNFL) thickness obtained by optical coherence tomography (y) and the degree of myopia (x). As myopia increased, there was a significant decrease in the average RNFL Thickness obtained by the Stratus OCT ( p=0.000, r=0.323).

Reference

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