J Korean Ophthalmol Soc.  2002 Jun;43(6):1081-1085.

3 Cases of Latanoprost Associated Herpes Simplex Keratitis

• Kim KE
• Moon JI
• Chung SK
• Baek NH

Abstract

PURPOSE: To report three cases in which herpes simplex keratitis developed after initiation of latanoprost.
METHODS
We experienced three patients with herpes simplex keratitis after latanoprost instillation, two patients with open angle glaucoma and one is congenital glaucoma. We preformed herpes simplex virus culture for two cases.
RESULTS
One patient with history of herpes simplex keratitis, resolution when latanoprost was stopped; antiviral therapy could not eradicate herpes simplex keratitis until latanoprost was discontinued. The second patient with latanoprost associated herpes simplex keratitis cleared with discontinuation of latanoprost and start of antiviral therapy. The third patient had resolution, only when latanoprost was stopped. The result of viral cultures for two cases was negative.
CONCLUSIONS
Clinicians should be aware of development or recurrence of herpes simplex keratitis when laranoprost is used for intraocular pressure control.

Keyword

Herpes simplex keratitis; Latanoprost

MeSH Terms

Glaucoma
Glaucoma, Open-Angle
Herpes Simplex*
Humans
Intraocular Pressure
Keratitis, Herpetic*
Recurrence
Simplexvirus