J Korean Ophthalmol Soc.  1971 Dec;12(4):175-179.

Mitomycin Instillation After Pterygium Surgery

• Shim WS
• Hahn YS
• Suh NJ
• Youn DH

Abstract

There have been several methods to prevent the recurrence after pterygium surgery, but no satifactory method has been brought forth. The value of mitomycin, which appeares to offer an important contribution to control the recurence of pterygium postoperatively, seems to be due to its anticancerous effect. Also it can be used himself easily. 1. We instilled Mitomycin solution after Pterygium surgery to the 85 eyes (77 Patients) visited to the department of Ophthalmology, Seoul National Univ. Hospital from July, 1969 to March, 1971. 2. Mitomycin solution was instilled three times a day since postoperative first day for one to two weeks. The solution was prepared by solving the Mitomycin-S in the 5cc of distilled water or Mitomycin-C in the 5cc of of physiologic saline sloution, so the concentration of solution was 0.4mg per cc. 3. We used bare sclera method in pterygium surgery and all the members of staffs and residents participated in. 4. Follow-up study was done by direct examinations or questionnaires. The period of the follow-up was at least 6 months to 26 months. We recieved the answers of 58 eyes, among which 56 eyes(96.6%) did not recur and only 2 eyes (3.4%) recurred. Of no recurrent cases 42 eyes (75%) were cosmetically satisfactory and 14 eyes (25%) were moderately satisfactory by means of the patients themselves evaluation. 5. Many authors said that the operative technique contributes to the rate of recurrence, so we compared the result of staffs' cases with that of residents' in 58 eyes. There was no significant difference in the recurrence rate between staff' and residents' cases inspite of the unskillful techniques of residents. 6. Sid effects of Mitomycin solution appeared in 2 eyes; one had corneal erosion and edema, another severe conjunctival congestion and chemosis which disappeared within a few days by ceasing the instilltation of mitomycin solution.

MeSH Terms

Edema
Estrogens, Conjugated (USP)
Follow-Up Studies
Humans
Mitomycin*
Ophthalmology
Pterygium*
Surveys and Questionnaires
Recurrence
Sclera
Seoul
Sudden Infant Death
Water
Estrogens, Conjugated (USP)
Mitomycin
Water