J Korean Pediatr Soc.  2003 Feb;46(2):203-206.

Two Cases of Castlema's Disease in Childern

• Kim EA
• Lee CG
• Kim HS

Abstract

Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutional symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone and other immunosuppressor drugs. The prognosis of the multicentric form is worse than the localized form since malignancies and severe infections may lead to a rapidly fatal outcome. Castleman's disease has been rarely reported at pediatric age in Korea. We experienced two cases of Castleman's disease detected at 3 and 5 years of age. They were presented with painless enlargement of submandibulars and axillary lymph nodes but had no associated symptoms. The lesions were excised and diagnosed as Castleman's disease, and no recurrence was noted during follow-up periods.

Keyword

Castleman's disease

MeSH Terms

Anemia
Blood Sedimentation
Fatal Outcome
Follow-Up Studies
Giant Lymph Node Hyperplasia
Hypergammaglobulinemia
Hypoalbuminemia
Korea
Lymph Nodes
Lymphoproliferative Disorders
Prednisone
Prognosis
Recurrence
Prednisone