J Korean Rheum Assoc.  2004 Jun;11(2):174-178.

A Case of SLE-systemic Sclerosis Overlap Syndrome Complicated with Nephrotic Syndrome

• Yoon BY
• Lee CH
• Han SH
• Lee YW

Abstract

Renal manifestations of systemic sclerosis are proteinuria, hypertension, azotemia and renal crisis. Mild proteinuria is common, but the nephrotic syndrome occurring in association with systemic sclerosis has been rarely reported. The majority of nephrotic syndrome cases are caused by glomerulonephritis in patients with an overlap syndrome of SLE and systemic sclerosis. This report suggests that the nephrotic syndrome can be an infrequent sequel of systemic sclerosis alone without glomerulopathy. A 38-year old woman was suffering from visual loss and headaches. She had Raynaud's phenomenon and thickened skin on nearly whole body. Urine protein was 4,950 mg/day and serum albumin level was 2.7 g/dL. The result of renal biopsy was renovasculopathy-compatible with systemic sclerosis.

Keyword

Systemic sclerosis; Nephrotic syndrome; Overlap syndrome

MeSH Terms

Adult
Azotemia
Biopsy
Female
Glomerulonephritis
Headache
Humans
Hypertension
Nephrotic Syndrome*
Proteinuria
Scleroderma, Systemic
Sclerosis*
Serum Albumin
Skin
Serum Albumin