J Korean Rheum Assoc.  2000 Sep;7(3):308-312.

A Case of Periosteal New Bone Formation Associated with Behcet? Disease

• Keum DJ
• Yang DK
• Kim KJ
• Jee SR
• Yun CH
• Lee SW
• Chung WT

Abstract

Behcet? disease is a recurring illness characterized by the triple symptom complex of aphthous stomatitis, genital ulceration, and uveitis. The disease is multisystemic disorder with involvement of skin, gastrointestinal tract, blood vessels, central nervous system, joints, and epididymis. Vascular involvement of Behcet? disease affects both arteries and veins and blood vessels of all sizes. Periosteal new bone formation is one feature of hypertrophic osteoarthropathy. Other features are clubbing and arthritis. Periosteal new bone formation on the bones of the lower extremities without other features of hypertrophic osteoarthropathy has been reported in patients with varicose veins, vitamin A intoxication, infantile cortical hyperostosis, tuberous sclerosis, congenital syphilis and chronic renal failure with hyperparathyroidism, and chronic venous insufficiency. However, periosteal new bone formation has not, to our knowledge, been described in patients with Behcet? disease yet although similar findings are occasionally noted in polyarteritis nodosa. We report a case of Behcet? disease complicated by leg swelling with periosteal new bone formation of right lower leg.

Keyword

Behcet? disease; Hypertrophic osteoarthropathy

MeSH Terms

Arteries
Arthritis
Behcet Syndrome
Blood Vessels
Central Nervous System
Epididymis
Gastrointestinal Tract
Humans
Hyperostosis, Cortical, Congenital
Hyperparathyroidism
Joints
Kidney Failure, Chronic
Leg
Lower Extremity
Male
Osteogenesis*
Polyarteritis Nodosa
Skin
Stomatitis, Aphthous
Syphilis, Congenital
Tuberous Sclerosis
Ulcer
Uveitis
Varicose Veins
Veins
Venous Insufficiency
Vitamin A
Vitamin A