J Korean Soc Biol Psychiatry.  2000 Jul;7(1):21-33.

Antidepressants and Related Drug Interactions

• Lee MS

Abstract

As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. This review provides a better understanding of drug-drug interactions often encountered in pharmacotherapy of depression. Drug interactions can be grouped into two principal subdivisions : pharmackinectic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug move from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In this review, emphasis is placed on antidepressant medications, how they are metabolized by the P450 system, and how they alter the metabolism of other drugs. When prescribing antidepressant medications, the clinician must consider the drug-drug interactions that are potentially problematic.

MeSH Terms

Absorption
Antidepressive Agents*
Catalytic Domain
Depression
Drug Interactions*
Drug Therapy
Metabolism
Plasma
Protein Binding
Antidepressive Agents