J Korean Soc Emerg Med.  2015 Jun;26(3):263-268. 10.0000/jksem.2015.26.3.263.

A Case of Acute Kidney Injury in A 62 Year Old Man Who Took Atractylodes Macrocephala Koidzumi

• Chung SH
• Bang KT
• Moon KM
• Rah YM
• Yun HJ
• Kang MK
• Kim JY
• Kim JR
• Lee DK
• Park JH
• Kim YH

• KMID: 2334030
• DOI: http://doi.org/10.0000/jksem.2015.26.3.263

Abstract

The drug inducing tubulointerstitial nephritis is a crucial cause of acute kidney injury. Use of herbal plants in disease treatment is generally practiced in Korea. Although there are a small number of case reports, tubulointerstitial nephritis caused by taking Atractylodes macrocephala Koidzumi in human has never been reported. A 62-year-old man visited our hospital with symptoms of systemic edema accompanied by reduced urine volume and dyspnea after taking herbal plant 1 week ago. Chest radiographs showed both sided pleural effusion. Blood test results showed elevation of serum blood urea nitrogen and creatinine level and urine test results showed hematuria and proteinuria. Renal biopsy result showed evidence of tubulointerstitial nephritis by tubulitis and inflammatory cell expansion in the interstitium was observed. The patient's renal function recovered after administration of active renal replacement treatment and conservative therapy such as supplementation of fluid and electrolytes, and there was no disease recurrence for 1 year. Therefore, this case proved that Atractylodes macrocephala Koidzumi could cause acute kidney injury by the drug induced tubulointerstitial nephritis in human.

Keyword

Herbal medicine; Nephritis; Acute kidney Injury; Renal dialysis

MeSH Terms

Acute Kidney Injury*
Atractylodes*
Biopsy
Blood Urea Nitrogen
Creatinine
Dyspnea
Edema
Electrolytes
Hematologic Tests
Hematuria
Herbal Medicine
Humans
Korea
Middle Aged
Nephritis
Nephritis, Interstitial
Plants
Pleural Effusion
Proteinuria
Radiography, Thoracic
Recurrence
Renal Dialysis
Creatinine
Electrolytes