Effect of Intravenous Fat Emulsion on Glyphosate Surfactant Herbicide-Induced Shock in a Rat Model: A Preliminary Study

Cho, Byul Nim Hee; Ryu, Seung; Yoo, In Sool; Ahn, Hong Joon; Kim, Gun Dong; Kim, Hun

Abstract

PURPOSE
Decontamination and supportive care are general types of treatment for glyphosate surfactant herbicide (GlySH) intoxication. However, no particular treatment for refractory shock has been established as a conventional therapy. Therefore, this study examined whether intravenous fat emulsion therapy (IFE) is effective on GlySH-induced shock.
METHODS
This preliminary study was conducted on 10 rats. After anesthesia and catheterization, shock was induced by GlySH infusion. After a stabilization period, animals were randomized to receive intravenous normal saline (Group 1) or 20% lipid emulsion (Group 2).
RESULTS
In the shock state, there was no significant difference between the two groups for systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP). In the post-management state, there was no significant difference between the two groups for SBP and MAP. However, there was a significant difference for DBP (Group 1, median 72.5 (IQR 52.8-74.6) mmHg; Group 2, median 77.6 (IQR 74.8-98.3) mmHg, p=0.016), SBP variation (Group 1, median 5.5 (IQR 1.6-11.1) mmHg; Group 2, median 25.6 (IQR 15.5-42.9) mmHg, p=0.008); DBP variation (Group 1, median -1.02 (IQR -4.69-11.0) mmHg; Group 2, median 21.1 (IQR 14.0-43.2) mmHg, p=0.008); MAP variation (Group 1, median 1.15 (IQR -2.6-11.0) mmHg; Group 2, median 23.2 (IQR 14.2-42.8) mmHg, p=0.008).
CONCLUSION
The IFE increased blood pressure when shock was induced using GlySH. However, further studies are required to determine what components induced the shock and permitted a response to the IFE.