J Korean Soc Endocrinol.  2005 Apr;20(2):118-119.

High Dose Hook Effect in Macroprolactinoma

• Kim MS

Abstract

No abstract available.

MeSH Terms

Prolactinoma*

Figure

• 

  Fig. 1 High-dose hook effect

Reference

1. Barkan AL, Chandler WF. Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the "high-dose hook effect": case report. Neurosurgery. 1998. 42:913–915.

2. Garcia-Webb P, Watson FE, Whiteside N. High-dose "hook" effect in measurement of somatotropin by two-site immunoradiometric assay. Clin Chem. 1986. 32:2102.

3. Zweig MH, Csako G. High dose hook effect in a two-site ZRMA for measuring thyrotropin. Ann Clin Biochem. 1990. 27(Pt 5):494–495.

4. Brensing KA, Dahlmann N, Entzian W, Bidlingmaier F, Klingmuller D. Underestimation of LH and FSH hormone concentrations in a patient with a gonadotropin secreting tumor: the high-dose "hook-effect" as a methodological and clinical problem. Horm Metab Res. 1989. 21:697–698.

6. Comtois R, Robert F, Hardy J. Immunoradiometric assays may miss high prolactin levels. Ann Intern Med. 1993. 119:173.

7. St-Jean E, Blain F, Comtois R. High prolactin levels may be missed by immunoradiometric assay in patients with macroprolactinomas. Clin Endocrinol (Oxf). 1996. 44:305–309.

8. Schofl C, Schofl-Siegert B, Karstens JH, Bremer M, Lenarz T, Cuarezma JS, Samii M, von zur Muhlen A, Brabant G. Falsely low serum prolactin in two cases of invasive macroprolactinoma. Pituitary. 2002. 5:261–265.

9. Petakov MS, Damjanovic SS, Nikolic-Durovic MM, Dragojlovic ZL, Obradovic S, Gligorovic MS, Simic MZ, Popovic VP. Pituitary adenomas secreting large amounts of prolactin may give false low values in immunoradiometric assays. The hook effect. J Endocrinol Invest. 1998. 21:184–188.

10. Haller BL, Fuller KA, Brown WS, Koenig JW, Eveland BJ, Scott MG. Two automated prolactin immunoassays evaluated with demonstration of a high-dose "hook effect" in one. Clin Chem. 1992. 38:437–438.