J Korean Continence Soc.  2006 Jun;10(1):38-43.

Effect of ABT-594 a Selective Nicotinic Agonist, on Voiding Function in Spinal Cord Injury Rat

• Rho H
• Lee SJ
• Chang SG

Abstract

PURPOSE
In this study we demonstrate effect of selective nicotinic agonist, ABT-594 on voiding in spinal cord injury rat.
MATERIALS AND METHODS
Spinal cord injury rat was made by complete resection of the spinal cord(T8~9) and checked cystometry three weeks after injury. In female Sprague-Dawley awake rats, an intravesical catheter was inserted through the bladder dome and intravenous catheter was inserted to right jugular vein. After the surgery, cystometry was performed by infusing saline into the bladder(0.08 ml/min). Cumulative doses of ABT-594 (0.01, 0.1, 1, 10 ug/kg) were injected intravenously in spinal cord injury rat at 1 hour intervals.
RESULTS
All dose(0.01~10 ug/kg) of ABT-594 did not affect the intercontraction interval(ICI), maximal voiding pressure(MVP), and pressure threshold(PT), and from voiding contraction to non-voiding contraction(from VC to NVC), voiding volume(VV), residual volume(RV). But moderate dose(1 ug) of ABT-594 significantly decreased number of non-voiding contraction(55.6+/-13.7% of control)(p<0.05).
CONCLUSION
These result suggest that the nicotinic agonist ABT-594 might in part affect voiding function through stimulation of serotonergic nerve to lumbosacral level in spinal cord injury rat.

Keyword

Spinal cord injury; Nicotinic agonist; ABT-594; Bladder

MeSH Terms

Animals
Catheters
Female
Humans
Jugular Veins
Nicotinic Agonists*
Rats
Rats, Sprague-Dawley
Spinal Cord Injuries*
Spinal Cord*
Urinary Bladder
Nicotinic Agonists