Recurrence of Gastric Adenocarcinoma and Its Relating Factors

Lee, Sun Il; Min, Byung Wook; Um, Joon Won; Kim, Seung Joo; Mok, Young Jae

Abstract

PURPOSE: The purpose of this study is to analyze the mode of recurrence and it's relating factors in gastric adenocarcinoma.
MATERIALS AND METHODS
1,446 patients who had been undergone gastrectomy for gastric adeno carcinoma from September 1983 to December 1996 (Department of Surgery, Korea University) were studied (median follow-up was 2.9 years). Of them, 243 patients who had been proven recurrence were studied on recurrence mode and clinicopathological factors.
RESULTS
The mean duration to recurrence was 22 months. The modes of recurrence were locore gional (30.0%), peritoneal (23.0%), hematogenous (19.3%) and distant lymph node metastasis (4.1%) in order. In 23.5%, more than 2 recurrent pattern were combined. Age, gross type, tumor size and stage were statistically significant to the mode of recurrence. The disease free survival was calculated: regional lymph node, number of lymph node, stage, and tumor emboli had statistical significance in all types of recurrence and in locoregional recurrence, tumor size was significant. Multivariate analysis showed that regional lymph node influenced the disease free survival period in all cases and tumor size in locoregional recurrence.
CONCLUSION
The number of positive regional lymph node and tumor size are important factors predicting the timing of recurrence after curative resection for gastric adenocarcinoma.