J Korean Assoc Oral Maxillofac Surg.  2013 Oct;39(5):207-216.

The impact factors on 5-year survival rate in patients operated with oral cancer

• Geum DH
• Roh YC
• Yoon SY
• Kim HG
• Lee JH
• Song JM
• Lee JY
• Hwang DS
• Kim YD
• Shin SH
• Chung IK
• Kim UK

Abstract

OBJECTIVES
The purpose of this study is to analyze clinical impact factors on the survival rate, and to acquire basic clinical data for the diagnosis of oral cancer, for a determination of the treatment plan with long-term survival in oral cancer patients.
MATERIALS AND METHODS
Through a retrospective review of the medical records, the factors for long-term survival rate were analyzed. Thirty-seven patients, among patient database with oral cancer treated in the Department of Oral and Maxillofacial Surgery at Pusan National University Hospital within a period from March 1998 to March 2008, were selected within the study criteria and were followed-up for more than 5 years. The analyzed factors were gender, age, drinking, smoking, primary tumor site, type of cancer, TNM stage, recurrence of affected region, and metastasis of cervical lymph node. The 5-year survival rate on the impact factors was calculated statistically using the Kaplan-Meier method.
RESULTS
By classification of clinical TNM at the 1st visit, there were 11 (29.7%) cases for stage I, 11 (29.7%) cases for stage II, 3 (8.1%) cases for stage III, and 12 (32.5%) cases for stage IV. The 5-year survival rate of total oral cancer patients after the operation were 75.7%, pathological TNM stage related 5-year survival rate were as follows: stage I 90.0%, stage II 81.8%, stage III 100% and stage IV 45.5%; in which the survival rate difference by each stage was significantly observed. The recurrence of cervical lymph node was the significant impact factor for the survival rate, because only 30.0% the survival rate in recurrent cases existed. During the follow-up, there were 15 (40.5%) patients with confirmed recurrence, and the 5-year survival rate of these patients was decreased as 46.7%.
CONCLUSION
The classification of clinical and pathological TNM stage, local recurrence after surgery, and metastasis of cervical lymph node after surgery were analyzed as the 3 most significant factors.

Keyword

Oral cancer; Survival rate; Neoplasm metastasis; Recurrence; TNM classification

MeSH Terms

Drinking
Follow-Up Studies
Humans
Lymph Nodes
Medical Records
Mouth Neoplasms*
Neoplasm Metastasis
Recurrence
Retrospective Studies
Smoke
Smoking
Surgery, Oral
Survival Rate*
Smoke

Figure

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  Fig. 1 Overall survival rate.

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  Fig. 2 Stage-specific survival rate (Log rank test: P=0.027).

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  Fig. 3 Histopathologic differentiation-specific survival rate in squamous cell carcinoma (Log rank test: P=0.000).

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  Fig. 4 Recurrence-specific survival rate (Log rank test: P=0.097).

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  Fig. 5 Neck nodal metastasis-specific survival rate (Log rank test: P=0.000).

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  Fig. 6 Distant metastasis-specific survival graphs (Log rank test: P=0.000).

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