J Korean Assoc Maxillofac Plast Reconstr Surg.  2008 Jul;30(4):395-398.

Bisphosphonate(zoledronic acid) related osteomyelitis on mandible: a case report

Affiliations
  • 1Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea. shalee@knu.ac.kr

Abstract

Bisphosphonate are a class of drugs with a chemical structure which inhibit bone resorption, actually used for metastatic bone disease, osteoporosis, Paget's disease and multiple myeloma. Significant complication associated with their use is reported recently : mandibular and maxillary osteomyelitis or osteonecrosis. So we here report our case about the patient who was diagnosed of prostate cancer in 2004 April and treated with bisphosphonate(Zoledronic acid-Zometa(R), Novartis Co.) intravenously every 3 to 4weeks at a dose of 4mg to prevent bone metastasis, and also, the patient who came to the hospital due to the bony exposure of mandible and pain in 2006 November and was diagnosed osteomyelitis of mandible as a result of biopsy, bone scan, PET CT examination.

Keyword

Bisphosphonate; Mandibular osteomyelitis; Prostate cancer; Metastatic bone disease

MeSH Terms

Biopsy
Bone Diseases
Bone Resorption
Humans
Mandible
Multiple Myeloma
Neoplasm Metastasis
Osteomyelitis
Osteonecrosis
Osteoporosis
Porphyrins
Positron-Emission Tomography
Prostatic Neoplasms
Porphyrins
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