J Korean Androl Soc.  1996 Dec;14(2):87-90.

A Correlation between Peripheral and Penile Serum Levels of Nerve Growth Factor in Healthy potent Controls

• Cho JS
• Lee SK
• Kim JW
• Lee HS
• Park HW

Abstract

Nerve growth factor (NGF) is a potent neurotrophin signaling protein, the best-known member of a family of similar neurotrophins. Specific neuronal populations depends upon the neurotrophins for normal function and disturbances in NGF and neurotrophin supply have been implicated in neurodegenerative disease, diabetes, and hypertension. In this study, we measured peripheral and penile serum levels of NGF in 16 healthy potent controls. NGF was determined by sandwich ELISA method. On the average, the differences between peripheral and penile serum levels of NGF was 0.01 ng/ml (p>0.05), but there was a little variation between individual peripheral and penile serum was similar to those of NGF in penile serum. The peripheral serum levels of NGF in patients with diabetic neuropathy may be used to predict neurogenic impotence.

MeSH Terms

Diabetic Neuropathies
Enzyme-Linked Immunosorbent Assay
Erectile Dysfunction
Humans
Hypertension
Male
Nerve Growth Factor*
Nerve Growth Factors
Neurodegenerative Diseases
Neurons
Penis
Nerve Growth Factor
Nerve Growth Factors