J Korean Androl Soc.  1993 Dec;11(2):115-120.

An Immunocytochemical Study Of Estrogen Receptor In The Prostate

• Lee TH
• Lee NK
• Park YH

Abstract

Estrogen has been proposed as an important etiologic factor in the pathogenesis of benign prostatic hyperplasia(BPH) in man. In this study, an immunocytochemical method involving the monclonal antibody ER-D5 reactive with the cytosol estrogen receptor(ER) was used to investigate prostatic tissues. Estrogen receptor was present in 11 of 25 BPH specimens, and in 5 specimens that were amenable to composition analysis, ER was present in both the epithelial and stromal components. Estrogen receptor was also found in normal prostate(1 of 1) and prostatic carcinoma(2 of 2). The finding of ER in human BPH supports the proposal that circulating estrogen has a role in the pathogenesis of this disorder.

MeSH Terms

Cytosol
Estrogens*
Humans
Prostate*
Prostatic Hyperplasia
Estrogens