Korean J Intern Med.  2016 Jul;31(4):762-771. 10.3904/kjim.2013.019.

Diagnostic yield of computed tomography-guided bone biopsy and clinical outcomes of tuberculous and pyogenic spondylitis

• Joo EJ
• Yeom JS
• Ha YE
• Park SY
• Lee CS
• Kim ES
• Kang CI
• Chung DR
• Song JH
• Peck KR

• KMID: 2327752
• DOI: http://doi.org/10.3904/kjim.2013.019

Abstract

BACKGROUND/AIMS
This study aimed to evaluate the efficacy of computed tomography (CT)-guided bone biopsy for the diagnosis of spinal infection and compared the clinical outcomes between tuberculous and pyogenic spinal infections.
METHODS
The retrospective cohort study included patients who received CT-guided bone biopsy at a tertiary hospital over the 13 years.
RESULTS
Among 100 patients, 67 had pyogenic spondylitis and 33 had tuberculous spondylitis. Pathogens were isolated from bone specimens obtained by CT-guided biopsy in 42 cases, with diagnostic yields of 61% (20/33) for tuberculous spondylitis and 33% (22/67) for pyogenic spondylitis. For 36 culture-proven pyogenic cases, Staphylococcus aureus was the most commonly isolated organism. Patients with pyogenic spondylitis more frequently presented with fever accompanied by an increase in inflammatory markers than did those with tuberculosis. Among all patients who underwent surgery, the incidence of late surgery performed one month after diagnosis was higher in patients with tuberculous infection (56.3%) than in those with pyogenic disease (23.3%, p = 0.026).
CONCLUSIONS
Results obtained by CT-guided bone biopsy contributed to prompt diagnoses of spinal infections, especially those caused by tuberculosis. Despite administration of anti-tuberculous agents, patients with tuberculous spondylitis showed an increased tendency to undergo late surgery.

Keyword

Spondylitis; Computed tomography; Biopsy; Tuberculosis; Percutaneous

MeSH Terms

Biopsy*
Cohort Studies
Diagnosis
Fever
Humans
Incidence
Retrospective Studies
Spondylitis*
Staphylococcus aureus
Tertiary Care Centers
Tuberculosis