J Korean Soc Transplant.
1998 Jun;12(1):111-116.
A Case of Renal Transplantation in A Patient with Fabry's Disease
- Affiliations
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- 1Department of General Surgery, Chonbuk National University Medical School, Korea.
- 2Department of Internal Medicine, Chonbuk National University Medical School, Korea.
- 3Institute for Medical Sciences, Chonbuk National University Medical School, Korea.
- 4Department of Internal Medicine, Presbyterian Medical Center, Korea.
Abstract
- Fabry's disease is a rare, inborn error, sex-linked disorder of glycosphingolipid metabolism with death occurring from myocardial or renal involvement at 4th or 5th decades. The primary metabolic defect lies in the deficient tissue activity of the enzyme alpha-galactosidase A which results in progressive accumulation of the specific neutral glycosphingolipids, cerebroside dihexoside(CDH) and cerebroside triihexoside(CTH), within the lysosomes of endothelial, perithelial and smooth muscle cells of the cardiovascular and renal systems predominantly. Clinical manifestations are sequelae of the anatomic and physiologic alterations produced by the progressive deposition of glycosphingolipid in the tissues. We report the first case of successful renal transplantation in a patient with Fabry's disease in Korea. The patient was a 33-year-old male. Fabry's disease was confirmed by measurement of serum alpha- galactosidase level and renal biopsy. Biopsy finding showed lamellar inclusion bodies on electron microscopy. Galactosidase activity was also markedly decreased. He has been well for 49 months.
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