J Korean Acad Rehabil Med.
2002 Oct;26(5):587-590.
Pain Relief Effect of Calcitonin Injection in Ovariectomized Rats
- Affiliations
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- 1Department of Rehabilitation Medicine, Hanyang University College of Medicine, Korea. gardendsg@hanmail.net
Abstract
OBJECTIVE
To confirm the effect of calcitonin injection relieving pain in ovariectomized rats. METHOD: Thirty five Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/ Kg), low dose calcitonin group (56 U/Kg), free calcitonin group, ovariectomy group, control group). To assess the pain in ovariectomized rats, the tail of rats were dived in waters of 50+/-1degrees C. Then the tail withdrawal time was measured (tail withdrawal test). The tail withdrawal test was performed in once a week for eight weeks.
RESULTS
1. At seven and eight weeks after injection, the tail withdrawal time of high and low dose calcitonin group compared with that of ovariectomy group were significantly prolonged (p<0.05). 2. At eight weeks after injection, the tail withdrawal time of free calcitonin group compared with that of ovariectomy group was significantly prolonged (p<0.05).
CONCLUSION
The effect of calcitonin injection relieving pain in ovariectomized rats was found.
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