Tuberc Respir Dis.  2015 Jul;78(3):190-195. 10.4046/trd.2015.78.3.190.

Predictors of Relapse in Patients with Organizing Pneumonia

• Kim M
• Cha SI
• Seo H
• Shin KM
• Lim JK
• Kim H
• Yoo SS
• Lee J
• Lee SY
• Kim CH
• Park JY

• KMID: 2320642
• DOI: http://doi.org/10.4046/trd.2015.78.3.190

Abstract

BACKGROUND
Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients.
METHODS
This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46).
RESULTS
Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), PaO2/FiO2, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively).
CONCLUSION
This study shows that FVC, PaO2/FiO2 and serum protein level at presentation can significantly predict relapse in OP patients.

Keyword

Cryptogenic Organizing Pneumonia; Recurrence; Vital Capacity

MeSH Terms

Cryptogenic Organizing Pneumonia
Follow-Up Studies
Humans
Methods
Multivariate Analysis
Pneumonia*
Recurrence*
Retrospective Studies
Tertiary Care Centers
Vital Capacity

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