Tuberc Respir Dis.  2014 Jul;77(1):13-17.

Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution

• Lee SJ
• Kang HJ
• Kim SW
• Ryu YJ
• Lee JH
• Kim Y
• Chang JH

Abstract

BACKGROUND
This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC).
METHODS
We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis.
RESULTS
Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death.
CONCLUSION
The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.

Keyword

Age Groups; Carcinoma, Non-Small-Cell Lung; Drug Therapy; Survival

MeSH Terms

Age Factors
Carcinoma, Non-Small-Cell Lung*
Drug Therapy*
Humans
Mortality
Multivariate Analysis
Retrospective Studies
Smoke
Smoking
Smoke

Figure

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  Figure 1 Flow diagram showing the enrollment process.

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