Yeungnam Univ J Med.  2006 Jun;23(1):19-25.

Myocardial Protective Effect of Histidine-Tryptophan-Ketoglutarate Solution and Cold Blood Cardioplegic Solution in Pediatric Cardiac Surgery

• Jung TE
• Lee DH
• Han SS

Abstract

BACKGROUND: There is limited data on comparisons between the effect of histidine-tryptophan-ketoglutarate (HTK) solution and cold blood cardioplegic (CBC) solution in pediatric cardiac surgery. The purpose of this study was to compare the myocardial protective effect of HTK solution and CBC solution in patients undergoing pediatric cardiac surgery. MATERILAS AND METHODS: We selected 49 patients with ventricular septal defect and atrial septal defect. HTK solution was used in 21 patients and CBC solution was used in 28 patents. HTK solution was given as a single dose, whereas CBC solution was used in the usual multi-dose method. The incidence of EKG change and concentration of Troponin T and CK-MB were compared for the evaluation of myocardial damage.
RESULTS
There were no significant differences in the incidence of ST, T segment change by EKG and serial cardiac enzyme levels between two groups.
CONCLUSION
These results suggested that the myocardial protective effect of HTK solution was similar to CBC solution in simple pediatric cardiac surgery.

Keyword

Cardioplegic solution; Myocardial protection; Congenital heart surgery

MeSH Terms

Cardioplegic Solutions*
Electrocardiography
Heart Septal Defects, Atrial
Heart Septal Defects, Ventricular
Humans
Incidence
Thoracic Surgery*
Troponin T
Cardioplegic Solutions
Troponin T