Yeungnam Univ J Med.  2013 Dec;30(2):141-144.

A Case of Aggravated Hyperplastic Gastric Polyps after Treatment with Long-term Proton Pump Inhibitors

• Kim HT
• Park JW
• Eom SH
• Kwak TY
• Hwang HS
• Kim YS
• Kwak DH
• Kim JH

Abstract

Hyperplastic gastric polyps (HPPs) are the most common type of gastric polyps. They are assumed to be caused by chronic inflammation and regenerative proliferation, although this has not been clearly investigated yet. Many studies suggested the development of fundic gland polyps and carcinoid during long-term proton pump inhibitor (PPI) therapy, but the relationship between PPIs and HPPs is still unclear. We encountered a patient who showed aggravation of HPPs after long-term use of PPIs. A 58-year-old male patient with liver cirrhosis visited our hospital because of hematemesis. We started PPI medication after confirming esophageal variceal bleeding and duodenal ulcer with blood clot in its base via emergency endoscopy. He took PPIs for three years because of an intractable duodenal ulcer. There was a marked increase in the size of the pre-existing polyps and in the development of new polyps. We presumed that the PPIs caused the aggravation of the HPPs, so we stopped their administration. After five months, the HPPs shrank and the polyps were partially degraded. More prospective studies are needed to investigate the relationship between HPPs and PPIs.

Keyword

Hyperplastic gastric polyp; Proton pump inhibitor

MeSH Terms

Carcinoid Tumor
Duodenal Ulcer
Emergencies
Endoscopy
Esophageal and Gastric Varices
Hematemesis
Humans
Inflammation
Liver Cirrhosis
Male
Middle Aged
Polyps*
Proton Pump Inhibitors*
Proton Pumps*
Protons*
Proton Pump Inhibitors
Proton Pumps
Protons