Tuberc Respir Dis.  2009 Oct;67(4):338-344.

Usefulness of Photodynamic Therapy in the Management of Early Central Lung Cancer: A Report of Three Cases

• Lee JH
• Jeon K
• Koh WJ
• Suh GY
• Chung MP
• Kim H
• Kwon OJ
• Han J
• Um SW

Abstract

In photodynamic therapy, a chemical photosensitizer is activated by light of a specific wavelength., Photodynamic therapy has been combined with bronchoscopy in patients who are ineligible for surgical resection in order to treat patients with early central lung cancer. Here, we describe 3 patients with early central lung cancer who were treated effectively using photodynamic therapy. Our experience shows that this approach is a useful modality in the therapy of these types of tumors.

Keyword

Photodynamic therapy; Early central lung cancer; Rigid bronchoscopy

MeSH Terms

Bronchoscopy
Humans
Light
Lung
Lung Neoplasms
Photochemotherapy

Figure

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  Figure 1 Patient 1, with superficial squamous cell carcinoma at the right upper lobe. (A) Bronchoscopic finding before photodynamic therapy (PDT): mucosal nodularity was shown around the orifice of the anterior segment of the right upper lobe (H&E stain, ×100). (B) Histologic examination before PDT: squamous cell carcinoma (H&E stain, ×100). (C) Bronchoscopic finding after PDT: decreased mucosal irregularity and fibrotic changes observed at the same site (H&E stain, ×100). (D) Histologic examination after PDT: chronic inflammation with fibrosis (H&E stain, ×100).

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  Figure 2 Patient 2, with superficial squamous cell carcinoma at the right upper lobe. (A) Bronchoscopic finding before photodynamic therapy (PDT): a small nodule was found on the opening of the right upper lobe bronchus (H&E stain, ×100). (B) Histologic examination before PDT: squamous cell carcinoma (H&E stain, ×100). (C) Bronchoscopic finding after PDT: only fibrotic changes were observed at the same site (H&E stain, ×100). (D) Histologic examination after PDT: dysplastic squamous epithelium (H&E stain, ×100).

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  Figure 3 Patient 3, with superficial squamous cell carcinoma at the right upper lobe. (A) Bronchoscopic finding before photodynamic therapy (PDT): a mucosal nodule was shown on the bifurcation of the anterior and posterior segments of the right upper lobe (H&E stain, ×100). (B) Histologic examination before PDT: squamous cell carcinoma (H&E stain, ×100). (C) Bronchoscopic finding after PDT: fibrotic changes were seen at the same site (H&E stain, ×100). (D) Histologic examination after PDT: chronic inflammation with fibrosis (H&E stain, ×100).

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