Tuberc Respir Dis.  2009 Jan;66(1):42-46.

A Case of Spontaneous Regression of Non-small-cell Lung Cancer

• Lee JK
• Kim DJ
• Won TS
• Park SH
• Son HS
• Cho SJ

Abstract

Lung cancer is one of the most prevalent cancers and it has the highest mortality of all forms of cancers. Although surgery, chemotherapy and radiotherapy are routinely used for the treatment of lung cancer treatment, little progress has been made in the treatment of this condition over the past 20 years. The histological subtype of squamous cell carcinoma (SCC) accounts for approximately 30% of all lung cancer patients. Spontaneous regression of non-small-cell lung cancer (NSCL) is an extremely rare phenomenon. Spontaneous regression of cancer (SR) is defined as a complete or partial, temporary or permanent disappearance of all or at least some the relevant parameters of soundly diagnosed malignant disease without any medical treatment or with treatment that is considered inadequate to produce the resulting regression.

Keyword

Spontaneous regression; Non-small-cell lung cancer; Treatment

MeSH Terms

Carcinoma, Squamous Cell
Humans
Lung
Lung Neoplasms

Figure

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  Figure 1 (A) Focal nodular radiopacity and infiltration on left lower lung field. About 8 cm sized lobulating mass in anteromedial basal segment of left lower lung. (B) Subcarinal, both hilar, parabronchial lymphadenopathy.

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  Figure 2 (A) Squamous cell carcinoma (SCC), moderately differentiated (H&E stain, ×40). (B) Individual cells show hyperchromatic nuclei with keratinization in cytoplasm. Frequent abnormal mitoses are seen (H&E stain, ×100). (C) Abnormal cell clusters in SCC. A keratinizing spindle cell with hyperchromatic nucleus is seen in upper left corner (H&E stain, ×100).

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  Figure 3 (A) Improved state of left lower lung infiltration. Previously noted lobulated mass in left lower lung show more decreased. (B) Small lymph nodes in parabronchial and A-P window are still remained.

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  Figure 4 About 5×6 cm sized large lobulating nodular mass with infiltration can be seen at left lower lung field. Both hilar areas appear prominent.

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  Figure 5 Ill defined air-space consolidation can be seen at left lower lung field. There is no pulmonary mass. Slight cardiomegaly is shown. Both hilar prominence are still remained.

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