Tuberc Respir Dis.  2007 Oct;63(4):378-381.

A Case of Concomitant Scrub Typhus and Leptospirosis

Affiliations
  • 1Division of Pulmonology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. drterry@hanyang.ac.kr

Abstract

Tsutsugamushi disease (Scrub typhus) is an acute, febrile illness caused by Orientia tsutsugamushi, which is transmitted to humans through chigger bites. Leptospirosis, a febrile disease caused by various pathogenic Leptospira, and is acquired by exposure to contaminated water and soil. Both diseases have been the most common acute febrile diseases in the autumn in Korea for many years. Concomitant leptospirosis and scrub typhus is quite rare. We report a case of a coinfection with leptospirosis and scrub typhus in a 51-year-old male who presented with fever, abdominal pain and acute dyspnea. The patient was diagnosed with as acalculous cholecystitis, acute respiratory distress syndrome, and septic shock caused by the infection. This is the first case report of a coinfection with leptospirosis and scrub typhus in Korea.

Keyword

Leptospirosis; Scrub typhus

MeSH Terms

Abdominal Pain
Acalculous Cholecystitis
Coinfection
Dyspnea
Fever
Humans
Korea
Leptospira
Leptospirosis*
Male
Middle Aged
Orientia tsutsugamushi
Respiratory Distress Syndrome, Adult
Scrub Typhus*
Shock, Septic
Soil
Trombiculidae
Water Pollution
Soil

Figure

  • Figure 1 Chest X-ray on admission reveals diffuse consolidation in the both lung fields and increased interstitial markings in the peripheral lung zones.

  • Figure 2 Abdominal ultrasonography shows suspicious parenchymal liver disease(A) and acalculous cholecystitis(B).

  • Figure 3 Chest CT shows diffuse ground-glass opacities and compact consolidations in the both lung fields(A & B).

  • Figure 4 Diffuse haziness in both lung fields has much improved on the follow-up chest X-ray(taken on the 14th day after treatment).


Reference

1. McBride AJ, Athanazio DA, Reis MG, Ko AI. Leptospirosis. Curr Opin Infect Dis. 2005. 18:376–386.
2. Tachibana N, Okayama A. [Tsutsugamushi disease (scrub typhus)]. Nippon Rinsho. 2007. 65:208–211.
3. Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, Lee SH. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics. 2007. 27:161–172.
4. Wang NC, Ni YH, Peng MY, Chang FY. Acute acalculous cholecystitis and pancreatitis in a patient with concomitant leptospirosis and scrub typhus. J Microbiol Immunol Infect. 2003. 36:285–287.
5. Watt G, Jongsakul K, Suttinont C. Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. Am J Trop Med Hyg. 2003. 68:89–91.
6. Lu PL, Tseng SH. Fatal septicemic melioidosis in a young military person possibly co-infected with Leptospira interrogans and Orientia tsutsugamushi. Kaohsiung J Med Sci. 2005. 21:173–178.
7. Guarner J, Shieh WJ, Morgan J, Bragg SL, Bajani MD, Tappero JW, et al. Leptospirosis mimicking acute cholecystitis among athletes participating in a triathlon. Hum Pathol. 2001. 32:750–752.
8. Monno S, Mizushima Y. Leptospirosis with acute acalculous cholecystitis and pancreatitis. J Clin Gastroenterol. 1993. 16:52–54.
9. Vilaichone RK, Mahachai V, Wilde H. Acute acalculous cholecystitis in leptospirosis. J Clin Gastroenterol. 1999. 29:280–283.
10. Barton LL, Escobedo MB, Keating JP, Ternberg JL. Leptospirosis with acalculous cholecystitis. Am J Dis Child. 1973. 126:350–351.
11. Inaba H, Sugawara Y, Oouchi K, Tomichi N, Sato S, Takikawa Y, et al. [A case of Tsutsugamushi disease complicated with cholecystitis]. Nippon Shokakibyo Gakkai Zasshi. 2004. 101:52–56.
12. Zaltzman M, Kallenbach JM, Goss GD, Lewis M, Zwi S, Gear JH. Adult respiratory distress syndrome in Leptospira canicola infection. Br Med J (Clin Res Ed). 1981. 283:519–520.
13. Ichimura K, Uchida Y, Arai K, Nakazawa K, Sasaki J, Kobayashi K, et al. Afebrile scrub typhus (Tsutsugamushi disease) with acute respiratory distress syndrome. Intern Med. 2002. 41:667–670.
14. Phimda K, Hoontrakul S, Suttinont C, Chareonwat S, Losuwanaluk K, Chueasuwanchai S, et al. Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. Antimicrob Agents Chemother. 2007. 51:3259–3263.
15. Kim YS, Yun HJ, Shim SK, Koo SH, Kim SY, Kim S. A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. Clin Infect Dis. 2004. 39:1329–1335.
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