Tuberc Respir Dis.  2007 Jun;62(6):536-539.

A Case of Tuberculous Lymphadenitis accompanying Papulonecrotic Tuberculid

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. basthma@hanmail.net, basthma@cau.ac.kr
  • 2Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.

Abstract

Lymphadenitis is a common manifestation in tuberculous diseases. However, papulonecrotic tuberculid is an uncommon cutaneous manifestation, and is considered an allergic reaction against tuberculous bacilli in tuberculous lesions other than the lymph nodes. A wide great variety of cutaneous manifestations arise over a period of a few weeks - i.e., papules, necrosis, crusted and atrophic scars. We described a 27-year-old woman with right cervical tuberculous lymphadenitis and skin lesions involving her arms, legs and both fingers. Histopathologically, a leukocytoclastic vasculitis with V-shaped epidermal necrosis was observed in the upper and deep dermis, including the good response to anti-tuberculosis therapy support the diagnosis of papulonecrotic tuberculid.

Keyword

Papulonecrotic tuberculid; Tuberculous lymphadenitis

MeSH Terms

Adult
Arm
Cicatrix
Dermis
Diagnosis
Female
Fingers
Humans
Hypersensitivity
Leg
Lymph Nodes
Lymphadenitis
Necrosis
Skin
Tuberculosis, Cutaneous*
Tuberculosis, Lymph Node*
Vasculitis

Figure

  • Figure 1 Erythematous crusted papules on the both forearm, knee and fingers.

  • Figure 2 A) V shaped necrosis on the epidermis (H&E stain, ×40). B) Leukocytoclastic vasculitis on the dermal vessel (H&E stain, ×200)


Reference

1. Mitsuishi T, Iida K, Kawana S. Papulonecrotic tuberuclid with spontaneous remission. J Dermatol. 2006. 33:112–114.
2. Morrison JG, Fourie ED. The papulonecrotic tuberculide. From Arthus reaction to lupus vulgaris. Br J Dermatol. 1974. 91:263–270.
3. Oh ST, Lee HJ, Yoon DH, Kim JW. A case of papulonecrotic tuberculid combined with erythema induratum. Korean J Dermatol. 1999. 37:1703–1705.
4. Williams JT, Pulitzer DR, DeVillez RL. Papulonecrotic tuberculid secondary to disseminated Mycobacterium avinum complex. Int J Dermatol. 1994. 33:109–112.
5. Sehgal VN. Cutaneous tuberculosis. Dermatol Clin. 1994. 12:645–653.
6. Jordaan HF, Van Niekerk DJ, Louw M. Papulonecrotic tuberculid. A clinical, histopathological, and immunohistochemical study of 15 patients. Am J Dermatopathol. 1994. 16:474–485.
7. Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM. Cutaneous tuberculosis: dignosis and treatment. Am J Clin Dermatol. 2002. 3:319–328.
8. Chuang YH, Kuo TT, Wang CM, Wang CN, Wong WR, Chan HL. Simultaneous occurrence of papulonecrotic tuberculide and erythema induratum and the identification of Mycobacterium tuberculosis DNA by polymerase chain reaction. Br J Dermatol. 1997. 137:276–281.
9. Sehgal VN, Bhattacharya SN, Jain S, Logani K. Cutaneous tuberculosis: the evolving scenario. Int J Dermatol. 1994. 33:97–104.
10. Kakakhel KU, Fritsch P. Cutaneous tuberculosis. Int J Dermatol. 1989. 28:355–362.
11. Yoon DJ, Ihm CW. Clinicopatholgical comparison of papulonecrotic tuberculid and pityriasis lichenoides et varioliformis acuta. Korean J Dermatol. 1982. 20:667–675.
Full Text Links
  • TRD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr