Tuberc Respir Dis.  2002 Jun;52(6):651-656.

Pulmonary Features of Hyperimmunoglobulin E (Job's)syndrome

• Min BJ
• Shin JS
• Lee IS
• Shin YK

Abstract

Hyperimmunoglobulin E syndrome, otherwise known as Job's syndrome, is an immune disorder characterized by an abnormal elevation of the circulating immunoglobulin E level, and recurrent infections of the skin and sinopulmo nar tract. The syndrome has various ppulmonary featurea, e.g., pneumonia, pneumatocele, pneumothorax, lung abscesses and empyema. We report a case of hyperimmunoglobulin E syndrome, with various respiratory clinical manifestation. Medical therapy, including prophylactic antibiotics, has been the cornerstone for the treatment of hyperimmunoglobulin E syndrome. Even if surgical intervention is required, minimal pulmonary parenchymal resection is recommended.

Keyword

Immunologic diseases; Immunologic deficiency syndromes; Phagocyte bactericidal dysfunction; Hyperimmunoglobulin E-recurrent infection syndrome; Job's syndrome

MeSH Terms

Anti-Bacterial Agents
Empyema
Immune System Diseases
Immunoglobulin E
Immunoglobulins
Immunologic Deficiency Syndromes
Job Syndrome
Lung Abscess
Phagocyte Bactericidal Dysfunction
Pneumonia
Pneumothorax
Skin
Anti-Bacterial Agents
Immunoglobulin E
Immunoglobulins