Tuberc Respir Dis.  1997 Dec;44(6):1419-1425.

A Case of Recurred Primary Mediastinal Nonseminomatous Germ Cell Tumor Associated with Klinefelters Syndrome

• Jin WJ
• Shin KS
• Park TH
• Suh JH
• Lee GL
• Roh YH
• Kim JR
• Lee SH

Abstract

Primary mediastinal nonseminomatous germ cell tumor associated with Klinefelter's syndrome is a rare disorder. We experienced a case of recurred primary mediastinal nonseminomatous germ cell tumor developed in a 24-year-old patient with Klinefelter's syndrome. The patient had been treated with surgery and combination chemotherapy under the diagnosis of primary mediastinal nonseminomatous germ cell tumor before. A round mass was found on the right lower lung field in the chest X-ray during follow up. The patient was diagnosed as recurred primary nonseminomatous germ cell tumor and Klinefelter's syndrome through tumor markers, peripheral blood karyotyping, and other tests including hormonal assay and was treated with combination chemotherapy and surgery again. When the patient is diagnosed as primary mediastinal nonseminomatous germ cell tumor, Klinefelter's syndrome and hematologic malignancies should be considered to be associated diseases and vice versa.

Keyword

Primary mediastinal nonseminomatous germ cell tumor; Klinefelters syndrome

MeSH Terms

Diagnosis
Drug Therapy, Combination
Follow-Up Studies
Germ Cells*
Hematologic Neoplasms
Humans
Karyotyping
Klinefelter Syndrome*
Lung
Neoplasms, Germ Cell and Embryonal*
Thorax
Biomarkers, Tumor
Young Adult