Korean J Urol.  2013 Sep;54(9):593-597.

Hospitalization Decreases Serum Prostate-Specific Antigen Values Compared With Outpatient Values in Patients With Benign Prostatic Diseases

• Yoon IS
• Shin TY
• Kim SI
• Park SK
• Jang HI
• Choi JB
• Ahn HS
• Kim YS
• Kim SJ

Abstract

PURPOSE
To investigate whether hospitalization influences serum prostate-specific antigen (PSA) values.
MATERIALS AND METHODS
Transrectal ultrasound-guided prostate biopsies were performed for detecting prostate cancer in 2,017 patients between February 2001 and April 2011 at Ajou University Hospital. Of those patients, 416 patients who were hospitalized for prostate biopsies, whose serum PSA values were measured at the outpatient department within 1 month of admission and also just after admission, and who had negative prostate biopsy results were included in the present study. We retrospectively reviewed the data of the 416 patients and compared the serum PSA values measured in the outpatient department with those measured during hospitalization.
RESULTS
Among all 416 patients, the interval between the two PSA measurements was 22.2 days (range, 3 to 30 days) and the prostate size measured by transrectal ultrasonography was 53.63 mL (range, 12.8 to 197.9 mL). Among all patients, mean serum PSA levels measured during hospitalization were significantly lower than those measured in the outpatient department (6.69 ng/mL vs. 8.01 ng/mL, p<0.001). When stratified according to age, the presence or absence of chronic prostatitis in the biopsy pathology, serum PSA levels, and prostate size, the serum PSA levels measured during hospitalization were significantly lower than those measured in the outpatient department in all subgroups, except in cases aged 20 to 39 years and those with PSA <4 ng/mL, in whom no significant differences were shown.
CONCLUSIONS
Hospitalization decreases serum PSA values compared with those measured on an outpatient basis in patients with benign prostatic diseases. Therefore, serum PSA values should be checked on an outpatient basis for serial monitoring.

Keyword

Hospital outpatient clinics; Hospitalization; Prostate-specific antigen

MeSH Terms

Aged
Biopsy
Hospitalization
Humans
Outpatient Clinics, Hospital
Outpatients
Prostate
Prostate-Specific Antigen
Prostatic Diseases
Prostatic Neoplasms
Prostatitis
Retrospective Studies
Prostate-Specific Antigen

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