Psychiatry Investig.
2009 Dec;6(4):299-305.
Decreased Serum Brain-Derived Neurotrophic Factor Levels in Elderly Korean with Dementia
- Affiliations
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- 1Department of Psychiatry, Dong Suh Mental Hospital and Paik Institute for Clinical Research, Inje University, Busan, Korea.
- 2Department of Psychiatry, Guduk Hospital, Busan, Korea.
- 3Department of Psychiatry, Dong Nam Hospital, Gimhae, Korea.
- 4Department of Psychiatry, Dong Suh Mental Hospital, Masan, Korea.
- 5Department of Psychiatry, Busan Paik Hospital, Inje Medical College, Busan, Korea.
- 6Department of Psychiatry, School of Medicine and Paik Institute for Clinical Research, Inje University, Busan, Korea. npkyh@chol.com
Abstract
OBJECTIVE
The primary purpose of this study was to investigate the differences in the serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia. METHODS: 171 individuals over 65 years were enrolled in this study. Screening for cognitive impairments was carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) of the mean MMSE-KC score, and these were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease, Korean version (CERAD-K) and the Geriatric Depression Scale (GDS). The Clinical Dementia Rating Scale (CDRS) and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnostic criteria were used for further evaluation. Subjects with a CDRS score of 1 or higher were classified as having Alzheimer's disease (AD), and subjects with a CDRS score of 0.5 were classified as having a mild cognitive impairment (MCI). Subjects with a CDRS score of 0 were classified as having aging-associated cognitive decline (AACD). Serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. RESULTS: The serum BDNF levels were significantly lower in the subjects with MCI and AD compared with the healthy controls (p<0.01). A significant correlation was found between the total MMSE-KC score and serum BDNF level (r=0.295; p<0.01). However, no significant correlation was observed between the severity of MMSE-KC and the total GDS score. A significant difference was found in the total score of GDS between the AACD group and subjects with AD (p<0.05). CONCLUSION: This study suggested that BDNF might be involved in the pathophysiology of cognitive decline in elderly people.
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